Investigation the influence of mechanochemical processing on solubility of verapamil hydrochloride

Dissolution of drugs is a very important factor that directly affects their potential application. Due to the fact solubility may act as limiting in process absorption drug, it can also affect its bio-availableness. More than 40 percent have property poor water, resulting potentially pharmaceutical products not reaching patients or full potential. This work examined possibility improving verapamil hydrochloride (VHCl) by applying mechanochemical treatment. The impact treatment on physiochemical properties was comprehended XRPD, FTIR and Raman spectroscopy, well FESEM analysis. Besides, particle size distribution determined. Solubility determined using UV-VIS spectroscopy. Finally, correlated with distribution, structural morphological characteristics.